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Figure 7 | Molecular Pain

Figure 7

From: Moderate hypoxia influences excitability and blocks dendrotoxin sensitive K+ currents in rat primary sensory neurones

Figure 7

The hypoxia-sensitive K+ current is sensitive to α-DTX. A) Current recordings (holding potential -80 mV, ΔV 10 mV) of a neurone showing reversibly decreased K+ currents in hypoxic solution. Application of 50 nM α-DTX in normoxic solution in the same neurone prevented the reduction of K+ currents in subsequently applied hypoxia. B) Current-voltage relation of six neurones with reduced K+ currents. After application of 50 nM α-DTX the amplitude of K+ currents did not further decrease in hypoxia. Bath: choline chloride, pipette: potassium fluoride.

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Molecular Pain

ISSN: 1744-8069

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