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Figure 1 | Molecular Pain

Figure 1

From: Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test

Figure 1

Spinal transmission in flexor responses induced by three different sine-wave electrical stimuli. (A) Attachment of electrodes to the right hind paw plantar surface and instep of the mice. Arrowheads indicate electrode. (B) Representative trace of each of three different sine-wave (5, 250 and 2000 Hz) stimulus-induced responses. The intensity of each stimulus was gradually increased. (C) Average electrical stimulation thresholds for vocalization and paw flexor responses. (D-F) Sensitivity of NK1, NMDA and AMPA/kainate antagonists on three different sine-wave (5, 250 and 2000 Hz) stimulus-induced responses in the EPF test. (G-I) Opposite effects on C- and A-fiber-mediated response by nerve injury in mice. Sensitivity was determined by EPF tests on day 7 after sciatic nerve injury. The data were analyzed using Student's t-test. Significance was set to *p < 0.05. Data in these figures are presented as means S.E.M. from experiments using at least 6 mice.

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Molecular Pain

ISSN: 1744-8069

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