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Figure 1 | Molecular Pain

Figure 1

From: Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-κB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

Figure 1

Time course analysis of mGlu2 and mGlu3 mRNA expression after L-acetylcarnitine treatment. For short term treatments (30, 60, 120, and 240 minutes) DRG cultures were challenged with a single application of L-acetylcarnitine (250 μM). For long term treatments (1 day and 4 days) L-acetylcarnitine (250 μM) was applied every 12 hrs to DRG cultures and total RNA was extracted at different time points. mRNA levels were normalized to the housekeeping gene, GAPDH, and compared to vehicle controls. Real-time PCR analysis shows that mGlu2 mRNA is upregulated after 60 minutes following LAC treatment. Data are expressed as mean values ± SEM *p < 0.05

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Molecular Pain

ISSN: 1744-8069

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