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Figure 5 | Molecular Pain

Figure 5

From: Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia

Figure 5

Reduction of behavioral sensitization (allodynia) and hyperalgesia after CFA injection in αCaMKII-F89G transgenic mice. A. The behavioral responses of animals to a non-noxious mechanical stimulus (No. 2.44 von Frey fiber, which elicited no response before a dorsal hindpaw CFA injection), were recorded 1 and 3 days after injection. The data were plotted as percentage positive responses to stimulation of the ipsilateral or contralateral hind paw of wild-type and αCaMKII-F89G transgenic mice. Inflammation induced less behavioral allodynia in αCaMKII-F89G transgenic mice then wild-type mice (P < 0.05; indicated by *). B. The behavioral responses of animals to a noxious thermal stimulus were recorded 1 and 3 days after the injection. The data were plotted as response latency to stimulation of the ipsilateral or contralateral hind paw of wild-type and αCaMKII-F89G transgenic mice. Inflammation induced less hyperalgesia in αCaMKII-F89G transgenic mice then wild-type mice (P < 0.05; indicated by *). C. Hindpaw edema was measured with a fine caliper in wild-type and αCaMKII-F89G transgenic mice.

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Molecular Pain

ISSN: 1744-8069

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