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Table 1 Cardiovascular functions of AA and its metabolites

From: Nociceptors in cardiovascular functions: complex interplay as a result of cyclooxygenase inhibition

AA Metabolite Receptor subtypes Secondary messenger mechanisms Tissue distribution of the receptors Cardiovascular functions of AA metabolites Ref.
PGD2 DP1, DP2 (CRTH2) Gs (DP1, 2), Gi, Gq, MAPK (DP2) Leptomeninges, Langerhan cells, Goblet and columnar cells in GI tract, Eosinophils for DP1, All tissues for DP2 Vasodilation, Vasoconstriction, Platelet deaggregation 1, 12
PGE2 EP1, EP3, EP3, EP4 Gs, Gi, Gq Kidney, Lung and Stomach for EP1, EP2 expressed in response to LPS and gonadotrophins, EP3 and 4 in all tissues Vasodilation, Vasoconstriction, Maintain renal blood flow and GFR, Vascular smooth muscle mitogenesis 1, 12, 15
PGI2 IP Gs (predominant), Gi, Gq Neurons, (primarily DRGs), Endothelial cells, Vascular smooth muscle cells, Kidney, Thymus, Spleen and Megakaryocytes Vasodilation, Inhibit platelet aggregation, Inhibit TXA2-induced vascular proliferation 1, 12, 21, 58
PGF FP Gq, EGFR Corpus luteum, Kidney, Heart, Lung and Stomach Vasoconstriction, Mitogenesis in heart, Inflammatory tachycardia, Renal functions 1, 12
TXA2 TP Gq, Gs, Gi, Gh, G12 Kidney, Heart, Lungs, Platelets and Immune cells Platelet aggregation, Vasoconstriction, Inflammatory tachycardia 1, 12, 58
20-HETE ? Gq, Tyrosine kinase, Increased conductance of L-type Ca2+ channels, Inhibition of Na+-K+-2Cl cotransporter ? Renal and cerebral artery contraction, Antagonize EDHF mediated vasorelaxation, Myogenic constriction, Regulate renal functions 1, 54
Leukotrienes (LTB4-E4) BLT1, BLT2 (LTB4), CysLT1, CysLT2 (LTC4-D4) ?Gi/Go (BLT1,2, CysLT1,2), Gα16 (BLT1,2) Leukocytes, spleen, thymus, bone marrow, lymph nodes, heart, skeletal muscle, brain and liver for BLT1, Most tissues for BLT2, Coronary smooth muscle contraction, Transient pulmonary and systemic hypertension 1, 54
EETs ? Gs, Tyrosine kinases, ERK1/2, p38 MAPK, Activation of Ca2+-activated K+ channels ? Renal and cerebral vasodilation, Renal vasoconstriction, Vascular smooth muscle and endothelial cell proliferation 1