Table 1 Cardiovascular functions of AA and its metabolites

DP1, DP2 (CRTH₂)

Gs (DP1, 2), Gi, Gq, MAPK (DP2)

Leptomeninges, Langerhan cells, Goblet and columnar cells in GI tract, Eosinophils for DP1, All tissues for DP2

Vasodilation, Vasoconstriction, Platelet deaggregation

EP1, EP3, EP3, EP4

Gs, Gi, Gq

Kidney, Lung and Stomach for EP1, EP2 expressed in response to LPS and gonadotrophins, EP3 and 4 in all tissues

Vasodilation, Vasoconstriction, Maintain renal blood flow and GFR, Vascular smooth muscle mitogenesis

IP

Gs (predominant), Gi, Gq

Neurons, (primarily DRGs), Endothelial cells, Vascular smooth muscle cells, Kidney, Thymus, Spleen and Megakaryocytes

Vasodilation, Inhibit platelet aggregation, Inhibit TXA₂-induced vascular proliferation

FP

Gq, EGFR

Corpus luteum, Kidney, Heart, Lung and Stomach

Vasoconstriction, Mitogenesis in heart, Inflammatory tachycardia, Renal functions

TP

Gq, Gs, Gi, Gh, G12

Kidney, Heart, Lungs, Platelets and Immune cells

Platelet aggregation, Vasoconstriction, Inflammatory tachycardia

?

Gq, Tyrosine kinase, Increased conductance of L-type Ca²⁺ channels, Inhibition of Na+-K+-2Cl cotransporter

?

Renal and cerebral artery contraction, Antagonize EDHF mediated vasorelaxation, Myogenic constriction, Regulate renal functions

BLT1, BLT2 (LTB₄), CysLT₁, CysLT₂ (LTC₄-D₄)

?Gi/Go (BLT1,2, CysLT_1,2), Gα₁₆ (BLT1,2)

Leukocytes, spleen, thymus, bone marrow, lymph nodes, heart, skeletal muscle, brain and liver for BLT1, Most tissues for BLT2,

Coronary smooth muscle contraction, Transient pulmonary and systemic hypertension

?

Gs, Tyrosine kinases, ERK1/2, p38 MAPK, Activation of Ca²⁺-activated K⁺ channels

?

Renal and cerebral vasodilation, Renal vasoconstriction, Vascular smooth muscle and endothelial cell proliferation