Figure 4

Blocking of ischemia-induced inward currents by ionotropic glutamate receptor antagonists and glutamate transporter inhibitors. A). A sample trace shows ischemia-induced inward currents from a lamina V neuron of a rat at the age of 10 days old. B). A sample trace shows the block of ischemia-induced inward currents by the glutamate receptor antagonists CNQX (20 μM) and APV (50 μM). The recording was made from a rat different from A. C). Inhibition of ischemia-induced inward currents by the glutamate transporter inhibitor TBOA (100 μM). The recording was made from a rat different from A and B. D). Summary of ischemia-induced inward currents in the absence (first bar, n = 4), in presence of CNQX and APV (n = 6), or in the presence of TBOA (n = 9). All recordings were made from lamina V neurons of the rats at the age of 10 days old.