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Figure 2 | Molecular Pain

Figure 2

From: Inactivation properties of sodium channel Nav1.8 maintain action potential amplitude in small DRG neurons in the context of depolarization

Figure 2

Block of TTX-s sodium channels alters the voltage dependent decrease in AP amplitude. Responses from a single small DRG neuron in the presence of 300 nM TTX (inset waveforms a-f on the right) demonstrate that AP amplitude increases with depolarization of membrane holding potential from -90 to -60 mV (inset waveforms a-c). From holding potentials of -60 to -25, AP amplitude decreases with depolarization (inset waveforms c-f), and this decrease can be fit with a single Boltzmann equation (dashed line in the main figure, V1/2 = -36.8 mV). The dotted lines in inset waveforms indicate 0 mV.

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Molecular Pain

ISSN: 1744-8069

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