Figure 4
From: Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia
Spinal TRPV1 agonist causes stroking allodynia in the hindpaw. The endogenous TRPV1 agonist NADA (1 or 10 nmol) or vehicle (VEH) was injected intrathecally (IT) and the hindpaws were stimulated with von Frey hairs of the indicated calibers 15 (A) and 60 min (B) or a cotton bud 15 (C) and 60 min (D) after the IT injection. Stars (*) above columns indicate significant effects of NADA vs. VEH while number signs (#) above horizontal bars indicate significant effects of NADA 1 nmol vs. NADA 10 nmol (# or * p < 0.05; n = 10 per group). Panels A and B, two-way anova; panels C and D one-way anova.