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Figure 4 | Molecular Pain

Figure 4

From: Frequency-dependent ERK phosphorylation in spinal neurons by electric stimulation of the sciatic nerve and the role in electrophysiological activity

Figure 4

U-0126 administration depressed wind-up in dorsal horn nociceptive neurons. A: The typical response of the dorsal horn nociceptive neuron following electrical stimulation of the sciatic nerve (2 ms, 2 mA). B: A photomicrograph of the dorsal horn and the camera-lucida drawings of recording sites in the dorsal horn. An arrow head indicates the lesion by DC current application through the recording electrode. C: Typical responses of a dorsal horn nociceptive neuron following repetitive electrical stimulation of the sciatic nerve before (upper trace) and after (lower trace) U-0126 application. D: The effect of U-0126 administration on the mean evoked responses of dorsal horn nociceptive neurons following repetitive electrical stimulation of the sciatic nerve (n = 12). Note that evoked responses were depressed following U-0126 administration in a dose-dependent manner (*: p < 0.05, **: p < 0.01).

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Molecular Pain

ISSN: 1744-8069

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