Figure 3

Delayed effects on cold sensitivity of chemical sympathectomy after SNI. A. Paw withdrawal thresholds to mechanical stimuli using a calibrated series of von Frey hairs were not different between the chemical sympathectomy group (sympX, n = 15) and vehicle treated group (control, n = 12). B. Cold response score was different between groups, lower in the sympathectomized group compared to the control group 8 weeks after SNI (* p < 0.01, n = 15 and 12, respectively) and 11 weeks after SNI (* p < 0.05, n = 9 and 6, respectively). C. Noxious mechanical response score was not different between groups. For all sensory modalities tested, responses measured in the paw ipsilateral to the SNI were significantly different from the responses of the contralateral paw (p < 0.05).