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Figure 2 | Molecular Pain

Figure 2

From: The activation of nicotinic acetylcholine receptors enhances the inhibitory synaptic transmission in the deep dorsal horn neurons of the adult rat spinal cord

Figure 2

Effects of nicotinic receptor agonists on sIPSCs in lamina V neurons. A, (a) A continuous recording of sIPSCs in the control and following the application of the selective α4β2 nAChR agonist RJR-2403 (100 μM). (b), A histogram shows the time course of changes in sIPSC frequency following the application of RJR-2403; time bin is 10 s. (c), The graph shows the individual result from 14 lamina V neurons. B, The experiment was similar to that shown in (A) except that the selective α7 nAChR agonist choline (10 mM) was tested. Similar results were obtained in 11 out of 13 neurons. C, A histogram shows relative sIPSC frequency following the application of nicotine (n = 9), RJR-2403 (n = 14), or choline (n = 13). sIPSC frequency before the applications of testing drugs is used as control and is scaled at 100%. Data represent Mean ± SEM; *P < 0.05.

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Molecular Pain

ISSN: 1744-8069

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