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Figure 2 | Molecular Pain

Figure 2

From: Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex

Figure 2

LTP induced by EPSP-AP protocol is blocked by PD98059. A: A scheme illustrating the LTP induction protocol consisting of 3 EPSPs and 3 APs (10 ms ahead) at 30 Hz, which are repeated 15 times with the interval of 5 s. B: LTP is induced by the EPSP-AP protocol. This protocol induces significant LTP in adult ACC neurons (n = 8). C: LTP is blocked by addition of PD98059 in the intracellular solution. Traces show averages of six EPSCs at baseline response (pre) and 30 min (post) after the EPSP-AP protocol (arrow). The dashed line indicates the mean basal synaptic response. D: Summary of the effects of PD98059 (50 μM, n = 7) and U0126 (50 μM, n = 6) on LTP induced by the EPSP-AP protocol. * P < 0.05 compared to baseline response.

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Molecular Pain

ISSN: 1744-8069

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