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Table 1 Table illustrates the chemokine response profile of acutely dissociated DRG cells from rats with and without peripheral nerve injury (n = 5/group). The cells were imaged while the various chemokines were added to the bathing solution. A rise in (Ca)i after chemokine application was indicative of the expression of a functional chemokine receptor. After chemokine application, capsaicin, high K+ and ATP were used to characterize the identity of the cells (see text). Note the upregulation of chemokine signaling at 14 and 28 days after peripheral nerve demyelination in isolated DRG cells ipsilateral to the nerve injury. There was also an upward trend in chemokine signaling in the cells isolated from the DRG contralateral to nerve injury at POD 14–28. By POD 35, chemokine responsiveness returned to baseline levels.

From: Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors

  Control POD 14 POD 28 POD 35
Chemokine Ipsilateral Contralateral Ipsilateral Contralateral Ipsilateral Contralateral Ipsilateral Contralateral
MCP-1 5.8% 7.9% 11.6% 2.5% 31.7% ** 15.1% 2.4% 0.0%
SDF1 5.8% 7.0% 2.3% 5.0% 25% ** 8.2% 7.3% 6.6%
RANTES 5.8% 7.0% 23.2% ** 2.5% 8.3% 13.6% 9.7% 3.3%
IP-10 9.6% 8.8% 0.0% 20.0% 21.1%* 8.2% 7.3% 6.6%
  1. *p < 0.01
  2. ** p < 0.05
  3. n = 5/age group