Figure 4
From: Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1
15d-PGJ 2 specifically activates TRPA1-expressing DRG neurons. Traces represent increased fluorescence ratios of DRG neurons cultured from TRPA1 WT (A) or knockout (B) mice in response to 15d-PGJ2, AITC and capsaicin. Panels A and B illustrate responses of neurons from separate calcium experiments (~100 neurons per experiment are illustrated). All experiments were performed in quadruplicate from cultures derived from 10 animals per genotype. Compound application is indicated by black bars (Caps, Capsaicin).