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Figure 7 | Molecular Pain

Figure 7

From: The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons

Figure 7

Small diameter neurons acquire the ability to fire repetitively after GRO/KC incubation. A, Examples of the voltage response to a 90 pA 1 second current injection in a control IB4-negative neuron (top) and in an IB4-negative neuron incubated overnight in GRO/KC (1.5 nM) (bottom). B. Examples of the voltage response to a 50 pA current injection in control (top) and GRO/KC incubated (bottom) IB4-positive neurons. Same scale as A. C, D: Average number of action potentials during a 1 second current injection as a function of current amplitude in IB4-negative (C) and IB4-positive (D) cells. *, significant difference between GRO/KC and control cells at the indicated current value (two-way RM ANOVA with Holm-Sidak post test). N = 8 to 14 cells per group; data combined from 3 different cultures.

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Molecular Pain

ISSN: 1744-8069

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