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Figure 7 | Molecular Pain

Figure 7

From: Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice

Figure 7

Effect of morphine on simultaneously recorded evoked cortical responses in the S1 and ACC. (A) Schematic diagram of the recording scheme of the multichannel probes placed in the S1 and ACC regions. (B) Example sweeps of sink currents in the ACC layer V (upper panel) and S1 layer II/III (lower panel) evoked by the high intensity electrical stimulation (10 mA, 0.5 ms duration and 0.1 Hz) in the hind paw. Example sweeps of evoked cortical sink currents after morphine treatment (5 mg/kg, 10 mg/kg and 20 mg/kg) and reversal by naloxone treatment were demonstrated. (C) Statistical analysis of the effect of morphine on simultaneously recorded S1 and ACC evoked sink currents. Data are presented as mean ± SEM. Amplitude of the sink current after morphine injection is expressed as a percentage of the amplitude of the sink current measured before morphine injection. * p < 0.05.

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Molecular Pain

ISSN: 1744-8069

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