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Figure 2 | Molecular Pain

Figure 2

From: Functional identification of NR2 subunits contributing to NMDA receptors on substance P receptor-expressing dorsal horn neurons

Figure 2

The voltage-dependence of NMDA receptor-mediated currents is a good indicator of NMDA receptor subtype expression. A-C show current responses to NMDA bath applied to the same NK1R+ neuron as in Figure 1. (A) NMDA-evoked current response is the same as in Figure 1. (B) Co-application of NMDA and UBP141, an NR2C/D preferring antagonist, induced a smaller inward current. The I-V relationship shows a more pronounced negative slope conductance. (C) Co-application of NMDA and EAB318, an NR2A/B preferring antagonist, induced NMDA receptor-mediated current with less negative slope conductance.

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Molecular Pain

ISSN: 1744-8069

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