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Figure 4 | Molecular Pain

Figure 4

From: Functional identification of NR2 subunits contributing to NMDA receptors on substance P receptor-expressing dorsal horn neurons

Figure 4

NK1R+ neurons express higher proportion of NMDA receptors with NR2C/D subunits than do NK1R- neurons. (A1) Individual NK1R+ and NK1R- neurons showed different degree of g(-90 mV)/g(MIC) ratio decrease following exposure to UBP141. (A2) Overall, NK1R+ neurons show significantly higher g(-90 mV)/g(MIC) ratio than NK1R- neurons (p < 0.05). (B1) Individual NK1R+ and NK1R- neuron showed increased g(-90 mV)/g(MIC) ratio when NMDA was applied in the presence of EAB318. (B2) In summary, EAB318 significantly increased g(-90 mV)/g(MIC) ratios in both NK1R+ and NK1R- lamina I neurons.

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Molecular Pain

ISSN: 1744-8069

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