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Figure 5 | Molecular Pain

Figure 5

From: Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein

Figure 5

Effect of targeted disruption of PSD-93 gene on physical dependence induced by repeated morphine injections. WT and KO mice were given morphine injections (10 mg/kg, s.c.) twice daily for 6 days plus a once-daily intraperitoneal injection of either saline or 0.3 mg/kg MK-801. Bars represent mean number of jumps in the 15-min period following a single naloxone injection (2 mg/kg) that was given 2 h after a final 10-mg/kg subcutaneous morphine injection. **P < 0.01 vs the saline + morphine group.

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Molecular Pain

ISSN: 1744-8069

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