A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis

Molecular Pain

Table 4 Brain regions activated for CBP and OA

Brain region	Session 1		Session 2		Session 1 > Session 2
	Coordinates x, y, z	Z-score	Coordinates x, y, z	Z-score	Coordinates x, y, z	Z-score
*CBP (Pain-Visual)*
mPFC (32/10)	2, 48, 2	10.5			6, 52, -8	5.85
R ACC (32)	-2, 38, 20	7.72			-2,38,20	4.31
L SFG (8)	-16, 32, 46	9.76			-16,30,44	6.91
R SFG (8)	16,22,52	7.66
NAc	6, 12, -10	8.46
L ITG (20)	-56, -8, -32	6.36
L PP (7)	-48, -72, 38	8.18			-46, -74,44	6.12
L MT			-64, -44, -10	4.12
OA *(Pain-Visual)*
R VLOFC (10/11)			44, 42, -14	6.27
L MFG (9/46)	-36, 42, 6	4.88			-38, 52, 12	4.19
R MFG (9/46)			-40, 36, 32	4.78
ACC (32)			-4, 38,22	4.96
L Ant Insula/IFG	-36, 28, -8	4.07			-36, 28, -8	4.39
ACC (24)	-8, 22, 28	4.34	6, 30, 26	4.57	-4, 24, 28	2.63
R MFG (8/9)	50, 14, 48	3.7	40, 18, 52	4.65
L Putamen			-22, 14, -2	4.59
SMA (6/8)	2, 8, 62	4.25	10,16,62	4.35
L Insula (48)	-36, 6,4	3.72	-40, 8, -6	5.12
R Insula (48)	42, 6, -4	5.75	38, 18, -8	3.09
R Putamen	26, 6, -2	3.23	-18, 14, -2	6.22
L Amygdala	-20, -6, -18	3.17
R Thalamus	14, -18, 2	5.6	16, -18, 4	4.39	12, -18, 0	4.00
L Thalamus	-8, -22, 0	6.14	-16, -16,4	4.42	-6, -22, 0	3.62
L SI/MI (3/4)			-38, -24,56	6.12
L S2	-54, -26, 24	4.87	-58, -28, 26	5.01
R S2	52, -28, 24	2.87	54, -24, 26	4.67
Pre-cuneus (7)			0, -52, 68	5.88
L PP (7)			-28, -52, 54	5.46
L MT			-56, -64,4	5.36
R PP			22, -76,48	5.5
L Visual cortex			-12, -80, -12	6.1

L = left; R = right; mPFC = medial prefrontal cortex; DLPFC = dorsolateral prefrontal cortex; S2 = secondary somatosensory cortex; M1 = primary motor cortex; ACC = anterior cingulate; SMA = supplementary motor area; LP = lateral parietal cortex; PP = posterior parietal cortex; IFG = inferior frontal gyrus; NAc = nucleus accumbuns; ITG = inferior temporal gyrus; SFG = superior frontal gyrus; MT = middle temporal cortex; VLOFC = ventrolateral orbitofrontal cortex. Numbers in parenthesis = Brodmann areas. Minus denotes left, posterior and ventral to the anterior commissure for x, y, and z mm, respectively.

ISSN: 1744-8069