Figure 2

Analgesic effects of gabapentin in the ICS and neuropathic pain models. A: Dose-dependent analgesia by gabapentin (i.p.). The paw pressure test was performed at 0.5 h after gabapentin injection at day 7 after ICS or nerve injury. B: Time course of gabapentin (3 mg/kg, i.p.) analgesia in the ICS model. C: Dose-dependent analgesia by gabapentin (i.c.v.). D: Time course of gabapentin (3 μg/kg, i.c.v.) analgesia in the ICS model. Data were normalized to the level in the control plus vehicle group. Data represent the means ± S.E.M. from 4–9 individual mice per group. *p < 0.05 versus control group. #p < 0.05 versus vehicle group.