Figure 6

Sumatriptan decreases the rate, but not the amplitude of miniature IPSCs. (A) Time course of miniature IPSC (mIPSC) rate during superfusion of sumatriptan (3 μM) and SR95531 (10 μM). (B) Raw current traces of miniature IPSCs before (control) and during superfusion of sumatriptan (3 μM). (C) Averaged traces of miniature IPSCs before and during superfusion of sumatriptan (3 μM). Cumulative distribution plots of miniature IPSC (D) inter-event interval and (E) amplitude, before and during sumatriptan (3 μM). (F) Bar chart of the mean rate and amplitude of miniature IPSCs in the presence of sumatriptan (3 μM), expressed as a percentage of the pre-sumatriptan level, ** denotes p < 0.01. Traces in (A – E) are from the same neuron.