Figure 1

Partial blockade of neuropathic pain in atx^+/- mice. (A, B) Partial blockade of mechanical allodynia and hyperalgesia in atx^+/- mice. Paw pressure tests (A) were carried out on days 3, 7 and 14 after the nerve injury, while thermal paw withdrawal tests (B) were carried out on day 14 after the nerve injury. (C, D) Complete and partial blockade of Aβ (2000 Hz)- and Aδ (250 Hz)-fiber stimulation-induced hypersensitivities in lpa ₁ ^-/- (C) and atx^+/- (D) mice, respectively. Behavior experiments were carried out on days 7 and 14 (C) and day 14 (D) after the nerve injury. All data represent the mean ± SEM from 5–6 separate experiments. *p < 0.05 compared with sham-operated mice; #p < 0.05 compared with wild-type mice with nerve injury.