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Figure 1 | Molecular Pain

Figure 1

From: Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice

Figure 1

An EphB receptor blocking reagent prevents thermal hyperalgesia after nerve injury. Repeated measurements are shown of thermal sensitivity of the foot withdrawal response in CCI- and sham-operated mice injected with EphB receptors blocking reagent EphB2-Fc (each 2 μg for continuous 3 days) and control vehicles PBS or IgG-Fc (2 μg). The arrow(s) indicates surgery (sham or CCI) or drug injection (i.t.) at the time point. Data represent changes of the withdrawals of the ipsilateral foot (A) and the contralateral (B). The numbers of mice in each group are shown in parentheses. **P < 0.01 indicate significant differences between sham group (Sham + PBS) and each of the other groups.

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Molecular Pain

ISSN: 1744-8069

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