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Figure 6 | Molecular Pain

Figure 6

From: Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury

Figure 6

The effect of spinal TLQP-62 (50 nM) application upon L4/L5 dorsal horn cell activity in intact anaesthetized rats. A & B. A dorsal horn cell that had very little spontaneous spike activity at baseline, developed very high frequency spontaneous firing, shown here 50 mins post TLQP-62. C. The effect of spinal TLQP-62 application upon spontaneous activity in individual dorsal horn cells. The number of action potentials over a 10 min period is shown at baseline and at 75 mins post TLQP-62. The logarithmic scale reflects the very intense effect of TLQP-62 in a subpopulation of cells. D. The effect of spinal TLQP-62 upon brush, pinch and acetone evoked activity in dorsal horn cells (n = 14). The mean number of action potentials evoked by each stimulus (duration 1.5 secs) is shown at baseline and at 75 mins post TLQP-62. *P < 0.05, **P < 0.001 ; Mann-Whitney U test).

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Molecular Pain

ISSN: 1744-8069

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