Genetic variation in the Catechol-O-Methyltransferase (COMT) gene and morphine requirements in cancer patients with pain

Table 1 Catechol-O-methyltransferase (COMT) genotype frequencies, allele frequencies and allele carriage in the total of 197 cancer patients

SNP (region)	Genotype	Genotype frequencies	Allele	Allele frequencies	Allele carriage
Rs2075507*	AA	0.26	A	0.53	0.80
(promoter)	AG	0.54	G	0.47	0.74
	GG	0.20
Rs737866	AA	0.61	A	0.78	0.94
(intron 1)	AG	0.33	G	0.22	0.39
	GG	0.06
Rs7287550	CC	0.53	C	0.72	0.91
(intron 1)	CT	0.38	T	0.28	0.47
	TT	0.09
Rs5746849	GG	0.18	G	0.43	0.68
(intron 1)	GA	0.49	A	0.57	0.82
	AA	0.33
Rs740603	AA	0.31	A	0.56	0.81
(intron 1)	AG	0.50	G	0.44	0.69
	GG	0.19
Rs6269	AA	0.40	A	0.62	0.84
(intron 2)	AG	0.44	G	0.38	0.60
	GG	0.16
Rs2239393	AA	0.40	A	0.62	0.84
(intron 3)	AG	0.44	G	0.38	0.59
	GG	0.16
Rs4818	CC	0.41	C	0.63	0.84
(exon 4)	CG	0.43	G	0.37	0.59
	GG	0.16
Rs4680 (Val158Met)	GG	0.22	G	0.44	0.66
(exon 4)	GA	0.44	A	0.56	0.78
	AA	0.34
Rs174699	CT	0.09	C	0.04	0.09
(intron 5)	TT	0.91	T	0.96	100.0
Rs165728	CT	0.10	C	0.05	0.10
(untranslated region)	TT	0.90	T	0.95	100.0

ISSN: 1744-8069