Figure 2
From: Transforming growth factor-β1 impairs neuropathic pain through pleiotropic effects
Delayed administration with TGF-β1 reversed existing nociceptive behaviour. Rats started to receive TGF-β1 treatment on day 7 post-surgery where both paw withdrawal latency and threshold to heat (A) and mechanical stimuli (B) respectively, had reached their lowest level. The 7-day infusion of recombinant TGF-β1 (2.5 μg) in the spinal cord of nerve injured-animals (indicated by the blue arrow) resulted in a significant increase of force (B) and latency (A) in eliciting paw withdrawal compared to saline treated animals. *p < 0.05, **p < 0.01, ***p < 0.001, TGF-β1-treated vs. saline-treated at each time point, ##p < 0.01, each time point vs. presurgery baseline (d0) in the group of injured-saline-treated rats, n = 6 per group.