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Table 1 A comparison of dorsal horn neuronal responses evoked using electrical and natural stimuli in MIA and saline-injected mice

From: Behavioural and electrophysiological characterisation of experimentally induced osteoarthritis and neuropathy in C57Bl/6 mice

 

MIA-injected

Saline-injected

A-fibre threshold (mA)

0.26 ± 0.05

0.25 ± 0.08

C-fibre threshold (mA)

1.07 ± 0.29

1.5 ± 0.25

A-fibre response (AP)

106 ± 15*

68 ± 10

C-fibre response (AP)

190 ± 35*

109 ± 13

Post discharge (AP)

215 ± 40

135 ± 20

Input (AP)

203 ± 34*

110 ± 22

Wind-up (AP)

257 ± 81

163 ± 37

   Hill slope

24.3 ± 3.1*

17.2 ± 1.9

Brush (AP)

28 ± 7

36 ± 15

Pinch (AP)

145 ± 20*

86 ± 15

Acetone (AP)

14 ± 6

10 ± 5

1°C

19 ± 7

16 ± 5

  1. Data are presented as mean ± S.E.M. for dorsal horn neurones recorded in MIA- (n = 12) and saline-injected mice (n = 13). AP represents the mean number of action potentials in response to either a peripheral electrical or 10 s natural stimulus. * p < 0.05.