Figure 1
From: NR2B receptor blockade inhibits pain-related sensitization of amygdala neurons
Ro-256981 inhibits pain-related sensitization of an individual amygdala neuron. Extracellular recordings of the responses (spikes/s) of one CeA neuron to brief (15s) graded mechanical stimulation (compression) of the knee. ( A) In the control period before arthritis, the neuron responded more strongly to noxious than to innocuous stimuli. ( B) The responses of the same neuron increased 5 h after induction of the arthritis in one knee. ( C) Administration of Ro-256981 (10 μM, concentration in the microdialysis probe; 15 min) into the CeA inhibited the increased responses. ( D) The inhibitory effect of Ro-256981 was largely reversible after wash out with ACSF for 30 min. ( A-D) Top traces show recordings of the force (g/30 mm2) applied to the knee joint with a calibrated forceps. Peristimulus time histograms show number of action potentials (spikes) per second. Insets show that spike size and configuration remained constant throughout the experiment.