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Figure 5 | Molecular Pain

Figure 5

From: Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation

Figure 5

Blockade of CBR2 antagonizes the MKP-3 induction by JWH015. Quantification and representative western blot of MKP-3 expression in LPS-stimulated microglia in the presence or absence of JWH015 (1 μM) with or without the CBR2 antagonist, AM630, or the CBR1 antagonist, AM281. JWH015 induced a significant increase in MKP-3 compared to the LPS alone groups at the 15 min incubation time point. However, AM630 significantly blocked JWH015's effects on MKP-3 expression. JWH015's effects on MKP-3 were not modified by AM281. *p < 0.05 vs. LPS alone and LPS + JWH015 1 μM groups.

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Molecular Pain

ISSN: 1744-8069

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