Skip to main content

Table 1 IC50 values (nM) for NTS1 and NTS2

From: Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity

Compound Structure rNTS1 rNTS2
Neurotensin pyroGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH 5.0 ± 0.7 9.0 ± 2
NT69L N-methyl-Arg-Lys-Pro-L-neo-Trp-tert-Leu-Leu-OH 2.2 ± 0.5 3.7 ± 0.4
JMV-431 Boc-Arg-ArgPro-Tyrø(CH2NH)-Ile-Leu-OH 4735 ± 135 19 ± 3.2
Levocabastine non peptidic > 10,000 2.7 ± 1.3
  1. Binding potencies of NT and related analogs were determined in competition experiments performed with HEK293 cells expressing either NTS1 or NTS2. Data represent means ± SEM of at least three independent experiments carried out in triplicate.