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Figure 2 | Molecular Pain

Figure 2

From: Enhanced quantal release of excitatory transmitter in anterior cingulate cortex of adult mice with chronic pain

Figure 2

Number of available vesicles and release probability after peripheral inflammation and nerve ligation. A and B, Number of available vesicles (A) and release probability (B) in control mice (n = 12), mice following CFA injection (n = 8), and mice with nerve ligation (n = 9). *p < 0.05. C, A model for enhanced quantal release in ACC synapses with chronic pain. In mice following CFA injection, both probability of transmitter release and number of available vesicles are increased in ACC synapses. In mice with nerve ligation, only probability of neurotransmitter release but not number of available vesicles increased in ACC synapses. Upregulated phosphorylation of GluR1 contributes to an increase of postsynaptic responsiveness in mice with nerve ligation.

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Molecular Pain

ISSN: 1744-8069

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