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Figure 2 | Molecular Pain

Figure 2

From: Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex

Figure 2

Reduced AMPA receptor-mediated EPSCs in GluA1-/- mice. (A) Input-output relationships for AMPA receptor-mediated EPSCs in WT (n = 7) and GluA1-/- (n = 6) mice (left). * P < 0.05 compared with WT mice. Traces showing averages of five AMPA receptor-mediated EPSCs with input stimulation at 9 V (right). (B) Paired-pulse facilitaion (PPF) did not differ in WT (n = 13) and GluA1-/- (n = 9) mice (left). Sample traces of PPF recorded from WT and GluA1-/- mice at the 50 ms interval (right). (C) Traces of mEPSCs recorded from WT and GluA1-/- mice (Top). Summary results showing the frequency and the amplitude of mEPSCs in ACC neurons from WT (n = 13) and GluA1-/- (n = 9) mice (Bottom, left). Cumulative probability plot showing the distribution of the inter-event interval and the frequency in WT (n = 13) and GluA1-/- (n = 9) mice (Bottom, right).

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Molecular Pain

ISSN: 1744-8069

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