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Figure 6 | Molecular Pain

Figure 6

From: Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex

Figure 6

Synaptic potentiation in the SSHL in GluA1-/- mice. (A) Diagram of a slice showing the placement of a whole-cell patch recording and a stimulation electrode in the SSHL. (B) LTP was induced in SSHL neurons in WT mice (n = 7 slices/6 mice). (C) LTP was lost in ACC pyramidal neurons from GluA1-/- mice (n = 7 slices/5 mice). (D) LTP was induced in SSHL neurons from WTCD1 mice (n = 6 slices/5 mice). (E) LTP was enhanced in SSHL neurons from GluA2-/- mice (n = 6 slices/5 mice). (B-E) The insets show averaged of five EPSCs at baseline responses and 30 min after the pairing procedure (arrow). The dashed line indicates the mean basal synaptic responses.

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Molecular Pain

ISSN: 1744-8069

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