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Table 1 Percentage of cells responding to chemokine application in dissociated DRG ipsilateral to nerve injury at POD 21

From: Increased chemokine signaling in a model of HIV1-associated peripheral neuropathy

Chemokine

Sham

gp120/hCD4

gp120/hCD4 +ddC

MCP1

3.2%

18.7%*

17.5% *

SDF1

4.8%

4.3%

40%**

IP10

6.5%

5.9%

7.5%

  1. *p < 0.05 and ** p < 0.01 when compared to sham
  2. Minimum of 50 cells/treatment group
  3. Calcium imaging was used to monitor the change in [Ca2+]i after chemokines were applied to acutely dissociated DRG from sham or injured rats. The number of cells responding to MCP1 application increased significantly by 21 days after gp120/hCD4 and following the combination of gp120/hCD4 and ddC treatment. The number of cells responding to SDF1 application increased only after the combination of gp120/hCD4 and ddC treatments.
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Molecular Pain

ISSN: 1744-8069

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