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Figure 3 | Molecular Pain

Figure 3

From: NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity

Figure 3

Colonic innervation from lumbosacral DRG neurons is reduced following RTX treatment. (a)Application of the retrograde tracer DiI into the colon wall revealed a 70% decrease in the number of DRG neurons that innervate colon as compared to controls (control 87 ± 12;RTX 26 ± 6;n = 5, p < 0.001). DiI neurons no longer co-localized with the TRPV1 receptor(b) (p < 0.0001) or the PAR2 receptor(c) (p < 0.0001) following RTX lesioning. However, there was no change in the expression of the NK1 receptor (d). Scale bars = 50 μm.

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Molecular Pain

ISSN: 1744-8069

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