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Figure 6 | Molecular Pain

Figure 6

From: Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording

Figure 6

Showing quantitative analysis of spatial plasticity of synaptic connection size in the hippocampal formation following bee venom (BV)-induced persistent nociception. A, stimulus intensity-network response functional curves showing the mean averaged number of field excitatory postsynaptic potential (fEPSP) that was reliably evoked (>20% baseline) across the 8 × 8 arrays with the increasing stimulus intensity in naïve, saline (Sal-control), and BV-inflamed group of slices. Note the significant increase in the number of fEPSP following BV-induced persistent pain with each suprathreshold stimulus intensity applied (30-199 μA). The number of slices for each group is shown in parentheses. *P < 0.05 vs. naïve control; #P < 0.05 vs. saline control. Error bars: ± S.E.M. B, effects of peripheral nerve impulses blockade on the BV-induced spatial plasticity of synaptic connection. Peripheral bupivacaine pre-treatment fully abolished BV-elicited increase of the number of fEPSP. *P < 0.05 vs. saline control or naïve; #P < 0.05 vs. BV-inflamed. Error bars: ± S.E.M.

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Molecular Pain

ISSN: 1744-8069

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