Dynamic regulation of the endocannabinoid system: implications for analgesia

Molecular Pain

Table 2 Summary of known biological actions of the endocannabinoid metabolites, and their effects in models of pain.

*Synonym*	CB ₁	CB ₂	*TRPV1*	*PPAR-α*	*Effects in pain models*	*Reference*
PGD2-EA	weak agonist	weak agonist			yet to be shown	[108, 113]
PGE2-EA		weak agonist			yet to be shown	[108, 113]
PGF2α-EA	agonist		weak agonist		pro-inflammatory, produces allodynia	[108, 113, 140, 141]
PGE2-G					pro-inflammatory, produces mechanical allodynia and thermal hyperalgesia	[108, 113, 117]
5,6-EET-EA		agonist			yet to be shown	[118]
15-HPETE-G				agonist	yet to be shown	[102]
2-(11,12)EG	agonist	agonist			yet to be shown	[119]
2-(14,15)EG	agonist	agonist			yet to be shown	[119]
2-(14,15)DHETE-G				agonist	yet to be shown	[121]

PGD2-EA = prostamide D2, PGE2-EA = prostamide E2, PGF2α-EA = prostamide F2α, PGE2-G = prostaglandin E2-glyceryl ester, 5,6-EET-EA = 5,6-epoxyeicosatrienoic acid ethanolamide, 15-HPETE-G = 15-hydroperoxyeicosatetraenoic acid glycerol ester, 2-(11,12)EG = 2(11,12-epoxyeicosatrienoyl)glycerol, 2-(14,15)EG = 2(14,15-epoxyeicosatrienoyl)glycerol, 2-(14,15)DHETE-G = 2-(14,15-dihydroxyeicosatetraenoic acid)-glycerol ester.

ISSN: 1744-8069