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Figure 1 | Molecular Pain

Figure 1

From: Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity

Figure 1

Increased Ca v α 2 δ 1 expression in spinal cord and DRG correlates with tactile allodynia in spinal nerve ligated and injury-free Ca v α 2 δ 1 TG mice. Unilateral L5 spinal nerve ligation (SNL) surgeries were performed in mice, and paw withdrawal thresholds (PWT) to von Frey filament stimulation were measured two-weeks post injury in SNL mice or in injury-free, adult male Cavα2δ1 TG and WT mice as described in the Methods. Data presented are the means ± SEM from n = 6 for the SNL group, and n = 12 each for the injury-free WT and TG groups. C – contralateral (non-injury) side. Ip – ipsilateral (injury) side. * p < 0.05 compared to contralateral side or WT control using unpaired Students' t test.

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Molecular Pain

ISSN: 1744-8069

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