|
RS cells
|
IM cells
|
IB cells
|
---|
|
control
|
Neuropathic pain
|
control
|
Neuropathic pain
|
control
|
Neuropathic pain
|
|
(n = 20)
|
(n = 13)
|
(n = 36)
|
(n = 29)
|
(n = 25)
|
(n = 19)
|
RMP, mV
|
-74.4 ± 2.3
|
-72.4 ± 2.2
|
-70.8 ± 1.8
|
-70.7 ± 3.0
|
-74.7 ± 1.1
|
-70.5 ± 1.4
|
AP threshold, mV
|
-34.4 ± 1.0
|
-37.5 ± 1.0
|
-35.2 ± 0.6
|
-33.3 ± 0.8
|
-36.0 ± 0.7
|
-35.4 ± 1.1
|
Input Resistance, mΩ
|
120.1 ± 13.6
|
146.8 ± 13.6
|
122.1 ± 12.1
|
133.3 ± 16.6
|
129.5 ± 8.0a
|
130.2 ± 9.8
|
Spike Height, mV
|
94.0 ± 2.7
|
88.3 ± 3.6
|
92.9 ± 1.4
|
93.6 ± 1.9
|
93.3 ± 1.3
|
89.4 ± 4.0
|
Spike Half Width, ms
|
1.66 ± 0.07
|
1.87 ± 0.17
|
1.46 ± 0.05a
|
1.57 ± 0.02
|
1.43 ± 0.04b
|
1.40 ± 0.07
|
fAHP Amplitude, mV
|
--------
|
--------
|
-7.0 ± 0.6
|
-8.2 ± 0.7
|
-6.8 ± 0.4
|
-6.4 ± 0.8
|
Time of fAHP, (ms)
|
--------
|
--------
|
5.0 ± 0.2
|
5.3 ± 0.4
|
4.0 ± 0.3d
|
3.9 ± 0.5
|
sAHP Amplitude, mV
|
-12.5 ± 0.7
|
-11.5 ± 0.8
|
-9.6 ± 1.6
|
-11.6 ± 0.8
|
-12.1 ± 0.8
|
-9.8 ± 1.0
|
Time of sAHP, ms
|
73.3 ± 7.4
|
70.8 ± 8.2
|
70.0 ± 3.9
|
56.5 ± 11.8
|
89.4 ± 7.6
|
71.2 ± 5.4
|
ADP, mV
|
--------
|
--------
|
1.5 ± 0.2c
|
1.3 ± 0.2
|
3.43 ± 0.40c, e
|
2.4 ± 0.4
|
Rise Time, ms
|
0.60 ± 0.03
|
0.66 ± 0.04
|
0.57 ± 0.02
|
0.54 ± 0.01
|
0.58 ± 0.02
|
0.56 ± 0.02
|
Rise Slope, mV/ms
|
132.4 ± 7.3
|
113.6 ± 11.4
|
137.0 ± 6.2
|
141.0 ± 3.5
|
136.9 ± 4.8
|
139.4 ± 7.8
|
Decay Time, ms
|
2.09 ± 1.12
|
2.01 ± 0.18
|
1.63 ± 0.06b
|
1.96 ± 0.12
|
1.53 ± 0.08c
|
1.44 ± 0.09
|
Decay Slope, mV/ms
|
-36.6 ± 2.9
|
-37.3 ± 4.9
|
-45.7 ± 1.9a
|
-37.9 ± 3.1
|
-50.9 ± 3.2a
|
-52.9 ± 4.5
|
Rheobase, nA
|
112.3 ± 8.5
|
106.9 ± 29.0
|
97.4 ± 7.6
|
80.3 ± 21.1
|
75.8 ± 3.7b
|
77.5 ± 19.5
|
- Values are means ± SEM; n is number of cells. ACC, anterior cingulate cortex; RMP, resting membrane potential; fAHP, fast afterhyperpolarization; sAHP, slow afterhyperpolarization; ADP, afterdepolarization.
-
aSignificantly different from RS cells at P < 0.05.
-
bSignificantly different from RS cells at P < 0.01.
-
cSignificantly different from RS cells at P < 0.001.
-
dSignificantly different from IM cells at P < 0.01.
-
eSignificantly different from IM cells at P < 0.001.