Table 1 Summary of basic electrophysiological and morphological parameters of ACC layer II/III pyramidal neurons in control and neuropathic pain mice.
| Â | RS cells | IM cells | IB cells | |||
|---|---|---|---|---|---|---|
| Â | control | Neuropathic pain | control | Neuropathic pain | control | Neuropathic pain |
| Â | (n = 20) | (n = 13) | (n = 36) | (n = 29) | (n = 25) | (n = 19) |
RMP, mV | -74.4 ± 2.3 | -72.4 ± 2.2 | -70.8 ± 1.8 | -70.7 ± 3.0 | -74.7 ± 1.1 | -70.5 ± 1.4 |
AP threshold, mV | -34.4 ± 1.0 | -37.5 ± 1.0 | -35.2 ± 0.6 | -33.3 ± 0.8 | -36.0 ± 0.7 | -35.4 ± 1.1 |
Input Resistance, mΩ | 120.1 ± 13.6 | 146.8 ± 13.6 | 122.1 ± 12.1 | 133.3 ± 16.6 | 129.5 ± 8.0a | 130.2 ± 9.8 |
Spike Height, mV | 94.0 ± 2.7 | 88.3 ± 3.6 | 92.9 ± 1.4 | 93.6 ± 1.9 | 93.3 ± 1.3 | 89.4 ± 4.0 |
Spike Half Width, ms | 1.66 ± 0.07 | 1.87 ± 0.17 | 1.46 ± 0.05a | 1.57 ± 0.02 | 1.43 ± 0.04b | 1.40 ± 0.07 |
fAHP Amplitude, mV | -------- | -------- | -7.0 ± 0.6 | -8.2 ± 0.7 | -6.8 ± 0.4 | -6.4 ± 0.8 |
Time of fAHP, (ms) | -------- | -------- | 5.0 ± 0.2 | 5.3 ± 0.4 | 4.0 ± 0.3d | 3.9 ± 0.5 |
sAHP Amplitude, mV | -12.5 ± 0.7 | -11.5 ± 0.8 | -9.6 ± 1.6 | -11.6 ± 0.8 | -12.1 ± 0.8 | -9.8 ± 1.0 |
Time of sAHP, ms | 73.3 ± 7.4 | 70.8 ± 8.2 | 70.0 ± 3.9 | 56.5 ± 11.8 | 89.4 ± 7.6 | 71.2 ± 5.4 |
ADP, mV | -------- | -------- | 1.5 ± 0.2c | 1.3 ± 0.2 | 3.43 ± 0.40c, e | 2.4 ± 0.4 |
Rise Time, ms | 0.60 ± 0.03 | 0.66 ± 0.04 | 0.57 ± 0.02 | 0.54 ± 0.01 | 0.58 ± 0.02 | 0.56 ± 0.02 |
Rise Slope, mV/ms | 132.4 ± 7.3 | 113.6 ± 11.4 | 137.0 ± 6.2 | 141.0 ± 3.5 | 136.9 ± 4.8 | 139.4 ± 7.8 |
Decay Time, ms | 2.09 ± 1.12 | 2.01 ± 0.18 | 1.63 ± 0.06b | 1.96 ± 0.12 | 1.53 ± 0.08c | 1.44 ± 0.09 |
Decay Slope, mV/ms | -36.6 ± 2.9 | -37.3 ± 4.9 | -45.7 ± 1.9a | -37.9 ± 3.1 | -50.9 ± 3.2a | -52.9 ± 4.5 |
Rheobase, nA | 112.3 ± 8.5 | 106.9 ± 29.0 | 97.4 ± 7.6 | 80.3 ± 21.1 | 75.8 ± 3.7b | 77.5 ± 19.5 |