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Table 1 Summary of basic electrophysiological and morphological parameters of ACC layer II/III pyramidal neurons in control and neuropathic pain mice.

From: Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury

  RS cells IM cells IB cells
  control Neuropathic pain control Neuropathic pain control Neuropathic pain
  (n = 20) (n = 13) (n = 36) (n = 29) (n = 25) (n = 19)
RMP, mV -74.4 ± 2.3 -72.4 ± 2.2 -70.8 ± 1.8 -70.7 ± 3.0 -74.7 ± 1.1 -70.5 ± 1.4
AP threshold, mV -34.4 ± 1.0 -37.5 ± 1.0 -35.2 ± 0.6 -33.3 ± 0.8 -36.0 ± 0.7 -35.4 ± 1.1
Input Resistance, mΩ 120.1 ± 13.6 146.8 ± 13.6 122.1 ± 12.1 133.3 ± 16.6 129.5 ± 8.0a 130.2 ± 9.8
Spike Height, mV 94.0 ± 2.7 88.3 ± 3.6 92.9 ± 1.4 93.6 ± 1.9 93.3 ± 1.3 89.4 ± 4.0
Spike Half Width, ms 1.66 ± 0.07 1.87 ± 0.17 1.46 ± 0.05a 1.57 ± 0.02 1.43 ± 0.04b 1.40 ± 0.07
fAHP Amplitude, mV -------- -------- -7.0 ± 0.6 -8.2 ± 0.7 -6.8 ± 0.4 -6.4 ± 0.8
Time of fAHP, (ms) -------- -------- 5.0 ± 0.2 5.3 ± 0.4 4.0 ± 0.3d 3.9 ± 0.5
sAHP Amplitude, mV -12.5 ± 0.7 -11.5 ± 0.8 -9.6 ± 1.6 -11.6 ± 0.8 -12.1 ± 0.8 -9.8 ± 1.0
Time of sAHP, ms 73.3 ± 7.4 70.8 ± 8.2 70.0 ± 3.9 56.5 ± 11.8 89.4 ± 7.6 71.2 ± 5.4
ADP, mV -------- -------- 1.5 ± 0.2c 1.3 ± 0.2 3.43 ± 0.40c, e 2.4 ± 0.4
Rise Time, ms 0.60 ± 0.03 0.66 ± 0.04 0.57 ± 0.02 0.54 ± 0.01 0.58 ± 0.02 0.56 ± 0.02
Rise Slope, mV/ms 132.4 ± 7.3 113.6 ± 11.4 137.0 ± 6.2 141.0 ± 3.5 136.9 ± 4.8 139.4 ± 7.8
Decay Time, ms 2.09 ± 1.12 2.01 ± 0.18 1.63 ± 0.06b 1.96 ± 0.12 1.53 ± 0.08c 1.44 ± 0.09
Decay Slope, mV/ms -36.6 ± 2.9 -37.3 ± 4.9 -45.7 ± 1.9a -37.9 ± 3.1 -50.9 ± 3.2a -52.9 ± 4.5
Rheobase, nA 112.3 ± 8.5 106.9 ± 29.0 97.4 ± 7.6 80.3 ± 21.1 75.8 ± 3.7b 77.5 ± 19.5
  1. Values are means ± SEM; n is number of cells. ACC, anterior cingulate cortex; RMP, resting membrane potential; fAHP, fast afterhyperpolarization; sAHP, slow afterhyperpolarization; ADP, afterdepolarization.
  2. aSignificantly different from RS cells at P < 0.05.
  3. bSignificantly different from RS cells at P < 0.01.
  4. cSignificantly different from RS cells at P < 0.001.
  5. dSignificantly different from IM cells at P < 0.01.
  6. eSignificantly different from IM cells at P < 0.001.
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