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Figure 3 | Molecular Pain

Figure 3

From: TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats

Figure 3

In CFA-inflamed rats, systemic administration of A-967079 (30 μmol/kg, i.v.) reduced (A) WDR responses to noxious pinch (28 mm mini bulldog clamp for 10 sec), and 10-g von Frey stimulation (n = 6 per group) of the RF on the hind paw. (B) Injection of A-967079 (30 μmol/kg, i.v.) also decreased the spontaneous firing of WDR neurons in CFA-inflamed rats (n = 6-12 per group). Since vehicle did not alter WDR firing in animals that received either a von Frey (n = 4) or pinch stimulus (n = 2), this data was combined for comparison. *p < 0.05, **p < 0.01 vs. baseline firing; ++p < 0.01 vs. vehicle-treated group (Fisher's LSD).

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Molecular Pain

ISSN: 1744-8069

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