Figure 10

Tactile (A) and thermal (B) sensory testing data for mice with established diabetes receiving either intranasal or intraperitoneal cannabinoid agents, with comparison to non-diabetic mice and saline delivery. Diabetic mice receiving medium and high doses of intranasal nabilone or WIN55212-2 had improvement of thermal hyperalgesia +/- tactile allodynia beginning at week 13 when interventions began. Stoppage of cannabinoid agents saw resumption of the full neuropathic pain state at week 21. For both tactile (A) and thermal (B) testing, significant differences were detected between the diabetic mouse group receiving moderate (γ) or high doses (θ) of intranasal cannabidiol or medium (χ) or high (τ) doses of intraperiteonal cannabidiol when compared to the diabetic mouse group receiving low dose intranasal or intraperitoneal cannabidiol at outset respectively (non-matched ANOVA tests, F-values range between 0.95-2.85 for indicated groups and time points, n ≥ 4, p < 0.05). Area under the curve (AUC) measurements were also significantly different between the same comparison groups in each case (p < 0.05). [n = 4-10 mice in each mouse cohort for each time point]