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Figure 2 | Molecular Pain

Figure 2

From: Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain

Figure 2

Tactile (A) and thermal (B) sensory testing data mice with or without diabetes. Significant differences were detected between the diabetic mouse and non-diabetic mouse groups (non-matched ANOVA tests, F-values range between 6.18-9.72 for indicated groups and time points, n ≥ 5, p < 0.05). Area under the curve (AUC) measurements were also significantly different between for the first 21 weeks of study (p < 0.05) [n = 5-10 mice in each mouse cohort for each time point]. Diabetic mice have a significant loss of sensory nerve action potential (SNAP) amplitudes (C) and sensory nerve conduction velocity (SNCV) (D) when compared to the non-diabetic mouse cohorts (non-matched ANOVA tests, F-values range between 2.13-5.88 for indicated groups and time points, n ≥ 5, p < 0.05) after 2-3 months of diabetes [n = 4-6 mice in each mouse cohort for each time point].

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Molecular Pain

ISSN: 1744-8069

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