|
Receptor
|
Signaling
|
Preferred Agonist
|
ΔCT (DRG)
|
|---|
|
P2Y1*
|
Gq/11
|
ADP
|
6.22 ± 0.11
|
|
P2Y2*
|
Gq/11
|
ATP = UTP
|
6.17 ± 0.08
|
|
P2Y4*‡
|
Gq/11
|
ATP = UTP
|
13.63 ± 0.31
|
|
P2Y6*
|
Gq/11
|
UDP
|
10.92 ± 0.14
|
|
P2Y12
|
Gi/o
|
ADP
|
7.55 ± 0.26
|
|
P2Y13**
|
Gi/o
|
ADP = IDP
|
9.78 ± 0.59
|
|
P2Y14
|
Gi/o
|
Glycosylated UDP
|
7.91 ± 0.59
|
- Relative expression levels of mRNA for P2Y family members in DRG are expressed as the normalized cycle threshold (ΔCT): the P2Y CT value minus the CT for the reference standard, GAPDH. *Previously published data [28]. ‡Rodent P2Y4 receptor shows equivalent responsiveness to ATP and UTP; the human receptor is selective for UTP. **Mouse but not human P2Y13 shows high affinity for IDP as well as ADP. P2Y11 is not included here because it is not expressed in rodents. (See [10, 37–39]).
