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Table 2 ADP evokes Ca++ transients through P2Y1.

From: Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior

  10 μM ADP 100 μM ADP MRS2179
100 μM ADP
wildtype    
% responders 35 ± 5% 52 ± 6% 8 ± 3%
n (cells) 37 197 40
wildtype    
response size (ΔF) 0.09 ± 0.01 0.53 ± 0.05 0.18 ± 0.02
wildtype    
response area (ΔFarea) 1 ± 2 11 ± 2 6 ± 1
P2Y1-/-    
% responders ND 9 ± 4% 10 ± 1%
n (cells)   100 55
P2Y1-/-    
response size (ΔF) ND 0.90 ± 0.28 1.31 ± 0.32
P2Y1-/-    
response area (ΔFarea) ND 15 ± 3 18 ± 4
  1. Dramatically fewer sensory P2Y1-/- neurons produce ADP-evoked calcium transients compared to wildtype neurons. Remaining responses in P2Y1-/- neurons are similar in size to those seen in wildtype. Similar effects were obtained using MRS2179, a P2Y1-specific antagonist. Frequency and response magnitude values are mean ± SEM.