|
Agonist (genotype)
|
ADP (wt)
|
IDP (wt)
|
UDPG (wt)
|
ADP (P2Y1-/-)
|
|---|
|
All DRG
| | | | |
|
Inhibition frequency
|
65 ± 7%
|
73 ± 4%
|
66 ± 10%
|
75 ± 7%
|
|
Inhibition magnitude
|
48 ± 5%
|
33 ± 4%
|
38 ± 4%
|
44 ± 4%
|
|
n(cells)
|
185
|
48
|
120
|
112
|
|
TRPV1+ DRG
| | | | |
|
Inhibition frequency
|
59 ± 9%
|
88 ± 13%
|
82 ± 8%
|
61 ± 14%
|
|
Inhibition magnitude
|
34 ± 22%
|
31 ± 6%
|
56 ± 10%
|
47 ± 9%
|
|
n(cells)
|
112
|
30
|
70
|
72
|
- P2YGi receptor agonists inhibit depolarization-evoked Ca++ transients in sensory neurons at 5 minutes after application. Table shows the percentage of sensory neurons in wild type and P2Y1-/- mice inhibited by each agonist and the magnitude of inhibition (change in peak response); values are given as mean ± SEM. Data are given for all sensory neurons, as well as for capsaicin-responsive cells (TRPV1+).
