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Table 3 Extent of inhibition by P2YGi receptor agonists.

From: Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior

Agonist (genotype)

ADP (wt)

IDP (wt)

UDPG (wt)

ADP (P2Y1-/-)

All DRG

    

Inhibition frequency

65 ± 7%

73 ± 4%

66 ± 10%

75 ± 7%

Inhibition magnitude

48 ± 5%

33 ± 4%

38 ± 4%

44 ± 4%

n(cells)

185

48

120

112

TRPV1+ DRG

    

Inhibition frequency

59 ± 9%

88 ± 13%

82 ± 8%

61 ± 14%

Inhibition magnitude

34 ± 22%

31 ± 6%

56 ± 10%

47 ± 9%

n(cells)

112

30

70

72

  1. P2YGi receptor agonists inhibit depolarization-evoked Ca++ transients in sensory neurons at 5 minutes after application. Table shows the percentage of sensory neurons in wild type and P2Y1-/- mice inhibited by each agonist and the magnitude of inhibition (change in peak response); values are given as mean ± SEM. Data are given for all sensory neurons, as well as for capsaicin-responsive cells (TRPV1+).
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Molecular Pain

ISSN: 1744-8069

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