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Table 3 Extent of inhibition by P2YGi receptor agonists.

From: Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior

Agonist (genotype) ADP (wt) IDP (wt) UDPG (wt) ADP (P2Y1-/-)
All DRG     
Inhibition frequency 65 ± 7% 73 ± 4% 66 ± 10% 75 ± 7%
Inhibition magnitude 48 ± 5% 33 ± 4% 38 ± 4% 44 ± 4%
n(cells) 185 48 120 112
TRPV1+ DRG     
Inhibition frequency 59 ± 9% 88 ± 13% 82 ± 8% 61 ± 14%
Inhibition magnitude 34 ± 22% 31 ± 6% 56 ± 10% 47 ± 9%
n(cells) 112 30 70 72
  1. P2YGi receptor agonists inhibit depolarization-evoked Ca++ transients in sensory neurons at 5 minutes after application. Table shows the percentage of sensory neurons in wild type and P2Y1-/- mice inhibited by each agonist and the magnitude of inhibition (change in peak response); values are given as mean ± SEM. Data are given for all sensory neurons, as well as for capsaicin-responsive cells (TRPV1+).