Table 1 Parameters of voltage-dependent activation and steady-state fast-inactivation of WT, P1308L, and V1298F Na_V 1.7_R channels.

V _{1/2, act}

k

n

V _{1/2, fast}

k

n

-21.8 ± 0.7

6.95 ± 0.11

29

-80.6 ± 1.1

6.32 ± 0.13

14

-31.4 ± 0.5*

7.33 ± 0.09*

25

-78.9 ± 0.7

5.65 ± 0.11*

13

-22.5 ± 0.7

6.83 ± 0.07

26

-64.5 ± 0.9*

5.45 ± 0.15*

13