Skip to main content

Table 1 Parameters of voltage-dependent activation and steady-state fast-inactivation of WT, P1308L, and V1298F NaV 1.7R channels.

From: Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel NaV1.7 produce distinct pain disorders

  Activation Steady-state fast inactivation
  V 1/2, act k n V 1/2, fast k n
WT -21.8 ± 0.7 6.95 ± 0.11 29 -80.6 ± 1.1 6.32 ± 0.13 14
P1308L -31.4 ± 0.5* 7.33 ± 0.09* 25 -78.9 ± 0.7 5.65 ± 0.11* 13
V1298F -22.5 ± 0.7 6.83 ± 0.07 26 -64.5 ± 0.9* 5.45 ± 0.15* 13
  1. * p < 0.05 P1308L or V1298F channels vs WT NaV1.7R channels.