Figure 4

No significant effect of NR2A/B or NR2C/D preferring antagonists on NMDA induced currents recorded from EGFP- neurons. The g(-90 mV)/g(MIC) values and VMIC are plotted for individual neurons and average values in the absence and presence of 25 μM UBP141 or 100 nM EAB318. Neither UBP141 or EAB318 significantly changed g(-90 mV)/g(MIC) and VMIC values (ns; no significance). Perforated lines indicate the conductance ratio of NR2A/B or NR2C/D receptor induced currents and VMIC derived from oocyte expression data of Kuner and Schoepfer [19].