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Figure 1 | Molecular Pain

Figure 1

From: The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation

Figure 1

BOLD response to laser stimulation. a) Group average. N = 57 subjects. GLM whole-brain analysis. Second-level mixed-effects FLAME. Cluster-corrected threshold Z = 3.5, p = 0.05. Upper row: 3 D surface projection. Lower row: axial slices. R = right. L = left. b) Two-group t-test. COMT met/met (N = 19) vs. COMT val carriers (N = 38). Voxel-by-voxel analysis restricted to the anterior cingulate cortex (according to the Harvard Oxford atlas). Second-level mixed-effects FLAME. Cluster-corrected threshold Z = 2.3, p = 0.05. Upper row: 3 D surface projection. Lower row: sagittal slices.

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