Glibenclamide reverses the Na
S-induced antinociception. In a different experiment we have analyzed the role of the KATP channels on the H2S-induced analgesia (panel A). Pre-treating rats with the KATP channels selective blocker glibenclamide (2.8 μmol/kg i.v.) completely reverses the Na2S-induced analgesia (panel B) without any effects on the change of the colonic compliance induced by Na2S. Data are mean ± SEM of 5 rats. *p < 0.05 versus CRD.